Mechanism of transcription factors KLFs in the occurrence and development of HCC
10.3969/j.issn.1000-8179.2016.08.047
- VernacularTitle:转录因子Klfs家族影响肝细胞癌发生发展的机制研究进展
- Author:
Xiao DONG
;
Qi LI
- Publication Type:Journal Article
- Keywords:
transcription factors;
Krüppel-like factor;
hepatocellular carcinoma;
tumor suppressor gene;
oncogene
- From:
Chinese Journal of Clinical Oncology
2016;43(8):348-351
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers in China. The specific molecular mechanism of its occurrence and development is unclear. Krüppel-like factor family (KLF), which includes 17 members, is a highly conserved transcrip-tion factor family with zinc finger structure. The mechanism of KLFs and the pathogenesis of HCC have been studied in recent years. Re-search revealed that KLF2, KLF4, KLF5, and other KLF family members could be involved in the progression of proliferation, differentia-tion, invasion, and metastasis of HCC. This review summarizes the function and the mechanism of transcription factors KLF in the oc-currence and development of HCC.
