The clinical application of prenatal serum blood group IgG antibody titer determination
10.3969/j.issn.1673-4130.2016.08.019
- VernacularTitle:孕妇产前Ig G血型抗体效价测定及临床应用
- Author:
Lifen LING
;
Xinjian ZHU
;
Bin LIU
;
Shuping NIE
;
Zhenhua LI
;
Nansheng CAI
- Publication Type:Journal Article
- Keywords:
hemolytic disease of newborn;
ABO blood group;
antibody titer;
microcolumn gel
- From:
International Journal of Laboratory Medicine
2016;37(8):1062-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relationship between the serum IgG antibody titer of pregnant women and the hemolytic dis‐ease of newborn(HDN) .Methods Using microcolumn gel coombs card assay method to determine titer of 255 cases of couples an‐tenatal serum IgG antibody and ABO blood group .Results with 195 cases of ABO‐incompatible couples ,the positive rate of abnor‐mal serum IgG antibody(≥64)was 93 .8% .The titer of anti‐A/B IgG :in 12(6 .2% ) cases was <64;in 12(6 .2% )cases was 64;in 60(30 .8% )cases was 128 ;in 39(20% )cases was 256 ;in 45(23 .0% )cases was 512 ;in 27(13 .8% ) cases was 1 024 .There were no statistical differences between IgG anti‐A(B) titers distribution between A/O blood group matching and B/O blood group matching (χ2 =4 .361 ,P=0 .499) ,IgG anti‐A( B) titers was higher in AB/O blood group matching .Conclusion we can take early and effec‐tive prevention ,treatment ,reducing the incidence of HDN by the determination of prenatal serum IgG antibody titers in ABO‐in‐compatible couples ,which is important for the population of eugenics .
