Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer
10.3969/j.issn.1671-167X.2016.02.023
- VernacularTitle:外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值
- Author:
Bin SHAO
;
Huiping LI
;
Lijun DI
;
Guohong SONG
;
Hanfang JIANG
;
Xu LIANG
;
Chaoying WANG
;
Ying YAN
;
Xiaolin LIN
;
Lina WANG
;
Fengling WAN
;
Yanhua YUAN
;
Miaoning YOU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Neoplasm metastasis;
Lymphocyte subsets;
Prognosis
- From:
Journal of Peking University(Health Sciences)
2016;48(2):304-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the proportion of lymphocyte subsets in peripheral blood of the ad-vanced breast cancer patients before and after chemotherapy with docetaxel and thiotepa,as well as the association between the proportion of peripheral blood lymphocyte subsets with the response rate and prog-nosis.Methods:The proportions of lymphocyte subsets (CD3 +T cell,CD3 +/CD4 +T cell,CD3 +/CD8 +T cell,CD3 -/CD16 +56 +NK cell,CD3 +/CD16 +56 +T cell,CD19 +B cell,CD4 +/CD25 +T cell,CD8 +/CD28 -T cell,CD8 +/CD28 +T cell)in the peripheral blood of 86 patients were analyzed with flowcytometry before and after chemotherapy.The result was analyzed in combination with clinico-pathological data.Results:The proportion of regulatory T cells (Treg)after chemotherapy in the disease control patients decreased significantly compared with that of the progressive patients (P=0.034).The difference of the proportions of Treg before and after chemotherapy affected significantly the overall survi-val (OS).The OS of the patients with decreased proportion of Treg was significantly longer than that of the patients with increased proportion of Treg,which was 23.5 and 9.4 months respectively (P<0.05). Conclusion:The patients with decreased proportion of Treg after chemotherapy had higher response rate and better survival benefit.
