NELL-1:a novel highly efficient and specific growth factor
10.3969/j.issn.1671-167X.2016.02.039
- VernacularTitle:NELL-1：高效特异的新型生长因子
- Author:
Xueyan QIN
;
Huaxiang ZHAO
;
Qian ZHANG
;
Feng CHEN
;
Jiuxiang LIN
- Publication Type:Journal Article
- Keywords:
Nell1 protein;
Bone morphogenetic protein 2;
Osteogenesis;
Chondrogenesis
- From:
Journal of Peking University(Health Sciences)
2016;48(2):380-383
- CountryChina
- Language:Chinese
-
Abstract:
SUMMARY Regenerationofbonetissue,aswellasothertissues,requiresinvolvementandinteraction of cells,scaffolds and relevant growth factors,among which growth factors play a crucial role in maintai-ning the stability of microenvironment.Nel-like-type 1 molecule (NELL-1 ),a novel growth factor in tis-sue engineering,has been studied intensively in recent years.Researches mainly covered gene and pro-tein structure and their expression profiling,biological function,molecular mechanisms and disease rele-vance.NELL-1 expressed in embryonic tissue is essential for growth and development of bone tissue. NELL-1 presents excellent abilities of inducing bone and cartilage regeneration,especially with high spe-cificity to chondrocyte lineage.Compared with classic osteogenic growth factor bone morphogenetic pro-tein 2 (BMP-2),the process of osteogenesis interacted with NELL-1 exhibits stronger specificity,higher bone density and fewerside effects.Furthermore,a recent study shows synergistic effects of NELL-1 and BMP-2.NELL-1 enhances the osteogenic reaction induced by BMP-2 of cells and notably declines in-flammation response caused by BMP-2.This review evaluates the current research progress of the function and application of NELL-1 by the systematic method of evidence-based medicine.
