Preparation of Triamcinolone Acetonide Acetate Thermosensitive Hydrogel and Its In Vitro Release
10.3870/j.issn.1004-0781.2016.05.020
- VernacularTitle:醋酸曲安奈德温敏凝胶的制备与体外释放度
- Author:
Min GUO
;
Hong LIU
;
Kefei JI
;
Kangping XIONG
;
Mengmeng ZHOU
;
Si GUO
- Publication Type:Journal Article
- Keywords:
Triamcinolone acetonide acetate;
Poly lactic-co-glycolic acid;
Polyethylene glycol;
Xanthan gum;
Thermosensitive hydrogel;
Release,in vitro
- From:
Herald of Medicine
2016;35(5):510-514
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare triamcinolone acetonide acetate(TAA)thermosensitive hydrogel for intra-articular injection,and to investigate its release in vitro. Methods TAA suspending thermosensitive hydrogel was prepared by using poly lactic-co-glycolic acid(PLGA)-polyethylene glycol(PEG)-PLGA as gel matrices,xanthan gum as suspending agent and NaCl as flocculant. It was evaluated preliminarily by determining its contents and its in vitro release. Results The best compositions for preparation of TAA suspending thermosensitive hydrogel were 25% PLGA-PEG-PLGA,0.05% xanthan gum, 0.9% NaCl and 4 mg·mL-1 TAA.The gelation temperature was 35.3 ℃ .The average recovery was(98.98±0.31)%. By the method of membraneless dissolution,the accumulative drug release was up to 83. 31% at 16 days. The drug release followed Ritger-Peppas methematical model. Conclusion The TAA thermosensitive hydrogel with obviously sustained release is expected to become a new drug delivery system for intra-articular injection.
