New research progresses on the prostate apoptosis response protein-4 for apoptosis induction cancer and its mechanism

VernacularTitle:Par－4特异诱导肿瘤凋亡及其机制的研究新进展
Author: Suiyi WU ; Bo HU ; Lianghua WANG
Publication Type:Journal Article
Keywords: prostate apoptosis response protein-4; tumor; extracellular pathway; apoptosis
From: Chinese Journal of Biochemical Pharmaceutics 2016;36(4):29-33
CountryChina
Language:Chinese
Abstract: Prostate apoptosis response gene-4(par-4)was first identified from the prostate tissue.This gene can express in both normal and cancer cells.The translation product of par-4 is prostate apoptosis response protein-4 ( Par-4 ) , which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected through intracellular and extracellular pathway.Par-4 is cleaved and phosphorylated by caspase3 and PKA; Par-4 transportsFas/FasL tocell membrane and activation of pro-apoptotic pathway;intracellular Par-4 transports GPR78 to cell membrane;extracellular Par-4 binds to GRP78 and activates it.There is a significant potential role in anti-tumors therapy of extracellular Par-4.The latest research progress on the mechanism of apoptosis induced by Par-4 and the treatment of exogenous Par-4 in tumor was discussed in this article.