- Author:
Yun Seok YANG
1
;
Hee Kyeong LIM
;
Kyung Kook HONG
;
Min Kyung SHIN
;
Jin Woo LEE
;
Sung Won LEE
;
Nack In KIM
Author Information
- Publication Type:Original Article
- Keywords: Adult acne; Comedone; Lipid peroxide; Oxidative stress; Smoking
- MeSH: Acne Vulgaris*; Adult*; Cytokines; Humans; Interleukin-1*; Interleukin-1alpha*; Oxidative Stress; Sebum; Smoke; Smoking; Tobacco Products*
- From:Annals of Dermatology 2014;26(1):11-16
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones. OBJECTIVE: To investigate the relationship of proinflammatory cytokines and LPO levels in the extracts of comedones with the acne of clinical difference between smokers and non-smokers, and with the severity and distribution of the acne lesions. METHODS: Twenty-two non-smoking and 21 smoking adult acne patients were evaluated by comedone extraction and measurement of proinflammatory cytokines and LPO levels. Acne severity and distribution of the lesions were also analyzed. RESULTS: Relative to the non-smoking group, smokers had significantly higher levels of IL-1alpha and LPO in comedones. Their levels showed a positive correlation. However, there were no statistically significant difference between the severity or distribution of the disease and the levels of LPO and IL-1alpha in comedones. CONCLUSION: Smoking may be involved in the pathogenesis of adult acne by increasing the oxidative stress that results in subsequent accumulation of LPO in comedones.