Effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on CRP, oxidative stress products and its efficacy in senile colpomycosis
10.3969/j.issn.1005-1678.2016.04.38
- VernacularTitle:妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎C反应蛋白、氧化应激产物的影响及其疗效
- Author:
Junxia NIU
;
Zhihui ZHANG
- Publication Type:Journal Article
- Keywords:
colpomycosis;
nifuratel and nysfungin;
Gynopathic antiphlogistic formula;
CRP;
oxidative stress products
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on serum levels of CRP, oxidative stress products and its efficacy in the treatment of senile colpomycosis.Methods 66 elderly patients of colpomycosis from October 2014 to December 2015 in department of obstetrics and gynecology of Nanxun Integrative Medicine Hospital were selected and randomly divided into two groups, 33 cases in each group.Patients in control group received nifuratel and nysfungin soft capsule, the experimental group received Gynopathic antiphlogistic formula on the basis of control group, with two courses, 6 days for one course.The serum inflammatory factors, oxidative stress products and clinical curative effect were compared.Results Compared with pre-treatment, the serum TNF α, CRP, IL-6, IL-8 levels decreased (P<0.05), SOD, NO increased (P<0.05), MDA, ET-1 decreased (P<0.05); compared with control group, the serum TNF α, CRP, IL-6, IL-8 level were lower (P<0.05), SOD, NO were higher (P<0.05),and MDA, ET-1 were lower (P<0.05).The clinical efficacy of experimental group was better than that of control group (Z=-2.902,P=0.004).Conclusion The Gynopathic antiphlogistic formula combined with nifuratel and nysfungin has a better efficacy in the treatment of senile colpomycosis, which could effectively reduce the serum levels of inflammatory factors, oxidative stress products with high safety.
