Efficacy of milrinone combined with dopamine in the treatment of elderly patients with refractory heart failure and the influence of levels of cardiac function and N-terminal B-type natriuretic peptide precursor
10.3969/j.issn.1005-1678.2016.04.52
- VernacularTitle:多巴胺联合米力农对老年顽固性心力衰竭临床疗效、心功能和N－末端B型利钠肽前体水平的影响
- Author:
Mingjuan SHI
;
Huamin YU
;
Haiying HE
;
Li YE
- Publication Type:Journal Article
- Keywords:
refractory heart failure;
Dopamine;
Milrinone;
NT-proBNP;
Heart function
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):164-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and investigate dopamine combined with milrinone treatment effect on elderly patients with intractable heart failure and N-terminal B-type natriuretic peptide level and cardiac function.Methods 80 cases of elderly patients with heart failure according to the number table method randomly divided into two groups: control group and experimental group, and control group was given conventional drugs.The patients in experimental group were received dopamine +Milrinone on the basis of control group.Clinical efficacy, N-terminal pro-B-type natriuretic peptide levels ( NT proBNP ) and heart function condition between two groups are compared and analyzed.Results The total effective rate of experimental group (95.00%) was higher than that of control group (70.00%) (P<0.05).NT-proBNP(2013.31 ±295.84)ng/L、LVEDD(61.48 ± 10.11)mm、LVEF(59.69 ±8.44)% in the experimental group was significantly better than the control group(P <0.05).Conclusion Dopamine combined with milrinone in the treatment of elderly patients with intractable heart failure is remarkable, can relieve the level of NT proBNP, and promote the recovery of cardiac function.
