Effect of deproteinized calf blood extractive injection combined with hyperbaric oxygen on hs-CRP, TNF-α, IL-6 and its efficacy in severe traumatic brain injury
10.3969/j.issn.1005-1678.2016.04.54
- VernacularTitle:小牛血去蛋白提取物联合高压氧对重型颅脑损伤患者hs－CRP、TNA－α、IL－6的影响及其临床疗效
- Author:
Heng ZHANG
;
Jianping HUANG
;
Bing CHEN
;
Kun YANG
;
Dengchong WU
;
Yidi HU
- Publication Type:Journal Article
- Keywords:
deproteinized calf blood extractive injection;
hyperbaric oxygen;
severe traumatic brain injury;
combination
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of deproteinized calf blood extractive injection combined with hyperbaric oxygen in patients with severe traumatic brain injury.Methods 74 patients with severe traumatic brain injury from January 2013 to March 2015 in Wenzhou hospital of Chinese traditional medicine were randomly divided into observation group and control group, 37 cases in each group.The control group received hyperbaric oxygen on the basis of conventional therapy, the observation group received deproteinized calf blood extractive injection on the basis of control group.The Glasgow coma scale ( GCS) , Barthel, hs-CRP, TNF-α, IL-6 and prognosis were compared between two groups.Results The GCS score and Barthel index scores post-treatment in observation group were (13.67 ±1.73),(65.73 ±4.02) points, which were higher than (9.66 ±1.24), (50.69 ± 3.76) points in control group, and the difference was significant (P<0.05).The serum hs-CRP, TNF-α, IL-6 post-treatment in observation group were (4.55 ±0.76)mg/L,(1.21 ±0.05)μg/L,(0.21 ±0.01)μg/L, which were better than those of control group (6.43 ±1.01)mg/L,(1.36 ±0.06)μg/L,(0.28 ±0.02)μg/L (P<0.05).The rate of favorable prognosis in observation group was 48.65%, which was higher than that of control group (P<0.05).Conclusion The deproteinized calf blood extractive injection combined with hyperbaric oxygen has the exact efficacy, which was better than hyperbaric oxygen alone in the treatment of severe traumatic brain injury.
