Bioinformatics analysis on the treatment mechanisms of Qishen-Yiqi fomular for ;myocardial infarction
10.3760/cma.j.issn.1673-4246.2016.05.015
- VernacularTitle:芪参益气方对心肌梗死治疗作用分子机制的生物信息分析
- Author:
Guanchuan LIN
;
Wenling ZHENG
;
Wenli MA
- Publication Type:Journal Article
- Keywords:
Qishen-Yiqi fomular;
Myocardial infarction;
Molecular mechanisms of pharmacological action;
Bioinformatics analysis
- From:
International Journal of Traditional Chinese Medicine
2016;38(5):436-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the age of big data, the treatment mechanisms of Qishen-Yiqi(QSYQ) for myocardial infarction was focused. Methods All the data stemmed from Gene Expression Omnibus (GEO). For ensuring the efficacy genetic molecular, differentially expressed genes were discobered by Qlucore Omics Explorer (QOE). And then gene set enrichment analysis was performed by Database for Annotation, Visualization and Integrated Discovery online Gene Annotation system(DAVID) for showing the genes functions during bioprocess. In the end, the predicted genes and proteins interactions networks were demonstrated by Gene/protein interaction database (STRING). Results The main biological process involved up regulating the expression of some specil genes such as NFIL3, ARNTL, DBP, FGD4 and nuclear receptor genes like NR1D1, NR1D2 while using QSYQ treatment. In such case, BHLHE40/41 was regulated. Conclusion Traditional Chinese medicine, QSYQ, could influence the expression of genes of cytothesis, inflammatory and enzymatic activity as its effect of the molecular mechanism, in order to treat and cure the myocarditis infarction.
