Molecular mechanism of Golgi protein 73 in inflammation
10.7644/j.issn.1674-9960.2016.04.009
- VernacularTitle:高尔基蛋白73参与炎症反应的分子机制研究
- Author:
Cui WANG
;
Congwen WEI
;
Deyong ZOU
;
Liping LIU
;
Qinfang HAO
;
Qi DING
;
Hui ZHONG
;
Xiaoli YANG
- Publication Type:Journal Article
- Keywords:
GP73;
neoplasm;
inflammation;
NF-κB;
interleukin;
tumor necrosis factorα
- From:
Military Medical Sciences
2016;40(4):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Golgi protein 73(GP73) on inflammation, and to reveal the effect of GP73 on tumorigenesis and metastasis.Methods The transcriptional activity of NF-κB and the expression of IL-1β, IL-6 and TNF-αwith GP73 overexpression or knockdown were detected to illuminate the role of GP73 in inflammation.According to the TCGA database, the correlation between the transcriptional activity of GP73 and the expression of NF-κB, IL-1β, IL-6 and TNF-αwas analyzed to determine the role of GP73 in tumor inflammation.Results Correlative analysis showed that there was a positive correlation between the expression of GP73 with NF-κB, IL-1β, IL-6 and TNF-α.The transcriptional activity of NF-κB was upregulated by GP73 overexpression, but downregulated by GP73 knockdown.The expression of IL-1β, IL-6 and TNF-αwas upregulated by GP73 overexpression.Ammonium pyrrolidinedithiocarbamate ( PDTC ) was in-volved in inflammation reaction induced by GP73.Conclusion GP73 is possibly involved in inflammation and promotes tu-morigenesis and metastasis.
