Effects of recombinant human interleukin-11 on the vaginal epithelium mitosis of estrone periodical mice and the expression of PCNA

VernacularTitle:重组人白细胞介素－11对雌激素周期性小鼠阴道上皮细胞有丝分裂和PCNA表达的影响
Author: Lijun CAO ; Jin WANG
Publication Type:Journal Article
Keywords: recombinant human interleukin-11; psoriasis; mitosis; PCNA
From: Chinese Journal of Biochemical Pharmaceutics 2016;36(4):49-51
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effects of recombinant human interleukin-11 (rhIL-11) on the vaginal epithelium mitosis of estrone periodical mice and the exprssion of PCNA.Methods The vaginal epithelium mitosis of estrone periodical mice was used as the epidermis hyperplasia model, rhIL-11 action in regulating the epidermis hyperplasia was observed and the expression of PCNA was detected by immunohistochemistry.Results The rhIL-11 significantly inhibited the mitosis of mouse vaginal epithelium, decreased the expression of PCNA ( P <0.01).Conclusion The rhIL-11 has good efficacy in treating the epidermis hyperplasia of psoriasis by inhibiting the mitosis of epithelium and decreasing the expression of PCNA.