Effect of oxiracetam on Hcy, hs-CRP, uric acid, cysteine protease inhibitors and blood lipid levels in patients with acute cerebral hemorrhage
10.3969/j.issn.1005-1678.2016.04.18
- VernacularTitle:奥拉西坦对急性脑出血患者Hcy、hs－CRP、尿酸、半胱氨酸蛋白酶抑制剂及血脂指标水平的影响
- Author:
Yanqiu GAO
- Publication Type:Journal Article
- Keywords:
oxiracetam;
acute cerebral hemorrhage;
homocysteine;
high sensitivity C-reactive protein;
uric acid;
cysteine proteinase inhibitors;
blood lipid index
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of oxiracetam on (Hcy), high sensitive C-reactive protein (hs-CRP), uric acid (UA) and cysteine protease inhibitor (Cys C) and blood lipid index level in patients with acute cerebral hemorrhage.Methods 98 patients with acute cerebral hemorrhage were randomly divided into observation group ( n =49 ) and control group ( n =49 ) .The control group was given routine treatment, the observation group was given oxiracetam treatment on the basis of control group.Two groups were treated for 2 weeks.Results The observation group after treatment NIHSS score lower than control group(P<0.05), GCS score and ADL score higher than control group (P<0.05);The serum levels of Hcy, hs-CRP, Cys, C levels lower than control group post-treatment, while the level of UA was higher than that of control group (P<0.05);The observation group TG, TC, LDL-C levels were lower than control group post-treatment ( P <0.05 ); Two groups had no severe adverse reactions. Conclusion Oxiracetam by reducing and Hcy in patients with acute cerebral hemorrhage hs-CRP, Cys C level, increased UA level, and improve blood lipid function, and thus improve symptoms.
