Effect of terazosin hydrochloride combined with finasteride on serum TNF-αand PSA in elderly patients with benign prostatic hyperplasia
10.3969/j.issn.1005-1678.2016.04.29
- VernacularTitle:盐酸特拉唑嗪联合非那雄胺片对老年良性前列腺增生患者血清TNF－α及PSA水平的影响
- Author:
Chengzhang WU
;
Shun LI
- Publication Type:Journal Article
- Keywords:
terazosin hydrochloride;
finasteride;
benign prostatic hyperplasia;
tumor necrosis factor α;
prostate specific antigen
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of terazosin hydrochloride combined with finasteride on serum TNF-αand PSA in old patients with benign prostatic hyperplasia.Methods 64 elderly patients of benign prostatic hyperplasia were randomly divided into 2 groups, 32 cases in each group.2 groups were given routine treatment and symptomatic treatment, the control group was given finasteride; the experimental group were treated with terazosin hydrochloride combined with finasteride.A cycle of 2 groups were 28 d, a total of 1 cycle of treatment.Clinical efficacy, maximum urinary flow rate, prostate volume, residual urine volume, international prostate symptom score(IPSS), serum tumor necrosis factor alpha, prostate specific antigen level and adverse reactions were compared after the end of treatment.Results Compared with before treatment, maximum urinary flow rate (Qmax) level of 2 groups increased, prostate volume, residual urine volume, international prostate symptom score(IPSS)decreased (P<0.05), compared with the control group, maximum urinary flow rate of the experimental group was higher (P<0.05), prostate volume, residual urine volume, IPSS were lower (P<0.05), 2 groups of TNF-αand PSA levels decreased after treatment (P<0.05), compared with the control group, TNF-αand PSA levels were lower(P<0.05).There was no significant difference in adverse reactions in 2 groups.Conclusion Terazosin hydrochloride combined with finasteride had a clinical efficacy of elderly patients with benign prostatic hyperplasia, can reduce serum TNF-αand PSA levels.
