Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population.
- Author:
Halit AKBAS
1
;
Selma Bakar DERTLIOGLU
;
Fuat DILMEC
;
Ahmet Engin ATAY
Author Information
- Publication Type:Original Article
- Keywords: Polymerase chain reaction-restriction fragment length polymorphism; PTPN22 gene; Vitiligo
- MeSH: Gene Frequency; Genotype; Humans; Melanocytes; Pigmentation; Polymorphism, Single Nucleotide; Vitiligo*
- From:Annals of Dermatology 2014;26(1):88-91
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders. OBJECTIVE: The aim of this study was to investigate whether the PTPN22 gene +1858 C>T single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population. METHODS: One hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The PTPN22 +1858 C>T genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls. CONCLUSION: We found no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.
