Effect of cetuximab combined with FOLFOX4 on expressions of PTEN and P13 K in colon cancer tissue of elderly patients
10.3969/j.issn.1005-1678.2016.04.50
- VernacularTitle:西妥昔单抗联合FOLFOX4对老年结肠癌患者组织PTEN及P13 K表达的影响
- Author:
Yijian YU
;
Lingyan YU
;
Shuangzhu WANG
- Publication Type:Journal Article
- Keywords:
cetuximab;
FOLFOX4;
elderly;
colon cancer;
PTEN;
P13K
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):158-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cetuximab combined with FOLFOX4 chemotherapy on expressions of cancer suppressor gene PTEN and P13K in colon cancer tissue of elderly patients.Methods 62 cases of elderly patients with colon cancer from October 2013 to July 2015 in our hospital were selected and divided into two groups according to the different therapy.The control group (n=27) received pure FOLFOX4 chemotherapy and treatment group(n=35)received cetuximab on the basis of FOLFOX4 chemotherapy, with a consecutive treatment of 4 courses.The clinical curative effect and expressions of PTEN and P13K in colon cancer tissue were compared between two groups.Results There were no significant difference in effective rate and disease control rate between treatment group and control group (51.4% vs.44.4%,χ2 =0.298,P=0.585;80.0%vs.62.9%,χ2 =2.223, P=0.136 ).After treatment, the cells positive rate of PTEN in treatment group was higher than that in control group post-treatment (82.86%vs.59.26%, P<0.05), and the cells positive rate of P13K in treatment group was lower than that in control group (37.14%vs.62.96%, P<0.05). Conclusion Cetuximab combined FOLFOX4 chemotherapy regimen could increase expression of PTEN and reduce P13K expression, which effect is remarkable in the treatment of elderly colon cancer.
