Effect of Levothyroxine Replacement Therapy on Improving Diffused Left Ventricular Myocardial Lesions in Patients With Hypothyroidism
10.3969/j.issn.1000-3614.2016.04.009
- VernacularTitle:左甲状腺素钠替代治疗改善甲状腺机能减退症患者左心室心肌弥漫性病变的研究
- Author:
Xia GAO
;
Min LIU
;
Ning YANG
;
Xinchun YANG
;
Guang WANG
- Publication Type:Journal Article
- Keywords:
Thyroid diseases;
T1 mapping;
Cardiomyopathies;
Thyroxin
- From:
Chinese Circulation Journal
2016;31(4):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of levothyroxine replacement therapy on improving diffused left ventricular myocardial lesions and cardiac function in patients with hypothyroidism. Methods: Our research included 2 groups: Hypothyroidism group,n=20 newly diagnosed patients and Control group, n=17 normal healthy subjects. Diffused left ventricular myocardial lesions were quantitatively evaluated by non-invasive cardiac MRI T1 mapping technique. Left ventricular myocardial T1 value and left ventricular function before and after levothyroxine replacement therapy were compared; the relationship between T1 value and thyroid function and the relationship between T1 value and the indicators of left ventricular function were analyzed. Results:①Compared with Control group, Hypothyroidism group had increased left ventricular myocardial T1 value, P<0.01, while decreased cardiac index (CI) and left ventricular peak filling rate (PFR), allP<0.05.②In patients with hypothyroidism, left ventricular myocardial T1 value was negatively related to serum FT3 level (r=-0.52,P=0.0006) and PFR (r=-0.43,P=0.0085).③Compared with pre-therapeutic condition, the patients with recovered normal thyroid function showed obviously decreased left ventricular myocardial T1 value and improved CI, PFR. Conclusion: Levothyroxine replacement therapy may improve diffused left ventricular myocardial lesions in patients with hypothyroidism, and therefore improve the cardiac function.
