Relationship Between β2-Adrenergic Receptor Gln27Glu Gene Polymorphism and Essential Hypertension Occurrence in Tibetan Population Living at High Altitude Area
10.3969/j.issn.1000-3614.2016.04.014
- VernacularTitle:β2肾上腺素能受体基因Arg16Gly和Gln27Glu多态性与高海拔地区藏族人群原发性高血压的相关性研究
- Author:
Xinghui LI
;
Yan QIAO
;
Yuan MA
;
Wenhua QI
;
Caixia LI
;
Baojuan LI
- Publication Type:Journal Article
- Keywords:
Receptors,adrenergic,beta-2;
Gene;
Hypertension;
Tibetan
- From:
Chinese Circulation Journal
2016;31(4):372-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate β2 adrenergic receptor (β2-AR) gene polymorphism, Arg16Gly, Gln27Glu and essential hypertension (EH) occurrence in Tibetan population living at high altitude area. Methods: Our research included in 2 groups: EH group, n=385 patients and Control group,n=297 normal healthy subjects. β2-AR polymorphisms of Arg16Gly and Gln27Glu were detected by Snapshot mini-sequencing technique and their frequencies were compared between 2 groups and male, female genders. Results: The genotype and allele frequency distributions of Arg16Gly and Gln27G1u were similar between 2 groups, P>0.05; there were no signiifcant differences between male and female genders,P>0.05. Conclusion: No obvious relationship was found between β2-AR gene polymorphism (Arg16Gly, Gln27Glu) and EH occurrence in Tibetan population living at high altitude area.
