Study on Silibinin Preformulation
10.3969/j.issn.1005-5304.2016.05.025
- VernacularTitle:水飞蓟宾处方前研究
- Author:
Yu ZHOU
;
Xinhua XIA
;
Chao LI
;
Chi ZHANG
- Publication Type:Journal Article
- Keywords:
silibinin;
equilibrium solubility;
apparent oil-water partition coefficient;
destructive test;
HPLC
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(5):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physical and chemical properties of silibinin; To lay foundation for optimal formulation design.Methods The high performance liquid chromatography method was used to detect the equilibrium solubility of silibininin in various solutions. The partition coefficients of silibinnin in the n-octalution-water and n-octalution-buffer solution systems were determined by shaking flask method. The destructive tests were carried out on silibinin.Results The equilibrium solubility of silibininin at 25℃ was 1.352 mg/L in water and the largest in acetonitrile, and increased in basic buffer solutions and after adding surfactants, of which sodium dodecyl benzene sulfonate was the strongest in solubilizing ability. The apparent oil-water partition coefficient of silibinnin was 61.39. Silibinnin was unstable in the acidic, basic, oxidizing and reducing solutions.Conclusion The experiment results can provide references for designing new preparations of silibinin.
