Reconstruction of the anterior cruciate ligament by allogeneic tendon graft：clinical curative effect and immune rejection
10.3969/j.issn.2095-4344.2016.15.009
- VernacularTitle:同种异体肌腱重建膝关节前交叉韧带：效果及免疫排斥反应
- Author:
Zesong TU
;
Lixue LIANG
;
Jisi XING
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(15):2190-2196
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Problems can occur at the donor site where the autologous tendon graft is taken. Alogenic tissue has become an important graft option for the reconstruction of the anterior cruciate ligament.
OBJECTIVE: To study the clinical curative effect and immune rejection of arthroscopic reconstruction of the anterior cruciate ligament by alogeneic tendon graft.
METHODS:The 120 included patients with anterior cruciate ligament injury were randomized into autologous tendon graft and alogeneic tendon graft groups, respectively, with 60 patients in each group. The autologous semitendinosus-gracilis graft at the affected side or the alogeneic anterior cruciate ligament was implanted into the knee joint in autologous tendon graft group or alogeneic tendon graft group, respectively. Lachman test results, Lysholm and Larson scores of joint function, and postoperative immune rejection were observed and assessed during 2-year folow-up.
RESULTS AND CONCLUSION: Lysholm and Larson scores in autologous tendon graft and alogeneic tendon graft groups were significantly increased after the reconstruction compared with before the reconstruction; however, there was no difference in the scores between both two groups at 2 years after the reconstruction (P > 0.05). At the end of the folow-up, the normal function of the knee joint was restored, and no lag and flexion constraint of the knee joint were observed. No significant differences were observed in Lachman test results between both groups (P> 0.05). Compared with the autologous tendon graft group, immune rejection rates were higher in the alogeneic tendon graft group; however, no significant differences were observed between both groups (P > 0.05). In summary, the alogeneic tendon graft may be a candidate for the reconstruction of the anterior cruciate ligament due to its similar clinical curative effect to the autologous tendon graft and low immune rejection rates.
