Advances in research of the role of microglia polarization in the mechanisms of pathogenesis of multiple sclerosis
10.3969/j.issn.1671-7856.2016.04.015
- VernacularTitle:小胶质细胞极化在多发性硬化发病中的作用机制研究进展
- Author:
Ming ZHANG
;
Jianghong LIU
;
Hao HONG
;
Linlin YIN
- Publication Type:Journal Article
- Keywords:
Microglia polarization;
Multiple sclerosis;
Central inflammatory reaction;
Pathogenesis;
Treatment
- From:
Chinese Journal of Comparative Medicine
2016;26(4):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Multiple sclerosis ( MS) is an autoimmune disease of the central nervous system ( CNS) characterized by demyelination and inflammation lesions.MS predominantly affects young adults with a high incidence of disability. However, the exact pathogenesis of MS is still not clear.Studies found that microglia polarization tending to pro-inflammatory M1-like state during the onset of MS, causing the M1/M2 ratio imbalance, forming pro-inflammatory microenvironment state, and which further leading to nervous tissue damage ultimately.Microglia polarization may be considered as the initiator of pathologic alterations by releasing pro-inflammatory cytokines and secondarily trigger the initial microglia response.Given the pivotal role of imbalanced microglia polarization in MS initiation, a critical review of microglia polarization is presented here, in order to elucidate the pathogenesis of MS and highlight the noteworthy candidate therapeutic targets for clinic treatment.
