Impact of four anesthetic drugs commonly used in animal experiments on the cardiovascular system in rats
10.3969/j.issn.1005-4847.2016.02.003
- VernacularTitle:四种常用实验麻醉药物对大鼠心血管系统的影响
- Author:
Anhui SUN
;
Jie GU
;
Tao WU
;
Zhaokai YUAN
;
Xiong CAI
;
Zhixi HU
;
Weixiong JIAN
;
Xin LI
- Publication Type:Journal Article
- Keywords:
Animal experiment;
Anesthetic drug;
Rat;
Cardiovascular system
- From:
Acta Laboratorium Animalis Scientia Sinica
2016;24(2):120-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of four different anesthetic drugs commonly used in animal experi-ments on cardiovascular system in rats.Methods Electrocardiogram ( ECG) and blood pressure were dynamically recor-ded by a BioPac MP150 system after anesthesia.In addition, the blood glucose at different time points and hepatic func-tion, kidney function, cardiac enzymes and electrolytes at the end of the test were collected.Rusults Chloral hydrate caused severe ventricular arrhythmia.Isoflurane had inhibitory effect on the heart rate.Pentobarbital sodium induced a in-crease of ECG P wave.Urethane caused J point elevation of ECG.Blood pressure in the urethane-and pentobarbital sodi-um-treated groups were increased.Chloral hydrate caused CK to be raised, while isoflurane showed the opposite effect on CK and CKMB.Alanine aminotransferase and aspartate aminotransferase in the pentobarbitol sodium and isoflurane groups were decreased.Creatinine in the chloral hydrate, pentobarbital sodium and isoflurane groups were lower, and the serum sodium and potassium were decreased in the four groups.Conclusions Chloral hydrate has obvious effect on the cardio-vascular system, and is not suitable for animal studies on cardiovascular diseases.Pentobarbital sodium, urethane, isoflu-rane can be chosen for animal studies on cardiovascular diseases.
