Research progress of adult animal models of growth hormone deficiency and bone metabolism
10.3969/j.issn.1005-4847.2016.02.019
- VernacularTitle:成年生长激素缺乏动物模型与骨代谢相关研究进展
- Author:
Renfei YUAN
;
Weimin DENG
;
Liping HAN
;
Xiaoxiang CHEN
;
Hairong SU
- Publication Type:Journal Article
- Keywords:
Growth hormone deficiency;
Animal model;
Bone metabolism;
Insulin-like growth factor-I
- From:
Acta Laboratorium Animalis Scientia Sinica
2016;24(2):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the establishment methods of animal models of adult growth hormone deficiency, and to provide a good model for experimental research and treatment for abnormal bone metabolism caused by growth hor-mone deficiency.Methods The methods of establishment of animal models of adult growth hormone deficiency were re-viewed and evaluated refering to literature.Results There were three methods including spontaneous lack-of, pituitecto-mized and gene knockout can establish animal models of adult growth hormone deficiency.Conclusions Hypophysecto-mized animal models are inexpensive and easy to create, but not suitable for studying the relationship between growth hor-mone and bone metabolism.Spontaneous lack-of and gene knockout models are specific growth hormone deficiency and of great research significance in exploring the relationship between growth hormone and bone metabolism.
