Measurement of serum levels of angiogenic factors and inflammatory cytokines in patients w ith moyamoya disease by cytometric bead array
10.3760/cma.j.issn.1673-4165.2016.02.003
- VernacularTitle:流式微球阵列法检测烟雾病患者血清血管生成因子和炎性细胞因子水平
- Author:
Xiangyang BAO
;
Bing ZHU
;
Yi LIU
;
Bing LIU
;
Lian DUAN
- Publication Type:Journal Article
- Keywords:
Moyamoya Disease;
Flow Cytometry;
Vascular Endothelial Growth Factors;
Angiopoietin-1;
Cytokines;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2016;24(2):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum levels of angiogenic factors and inflammatory cytokines in patients w ith moyamoya disease and explore their roles in the pathogenesis of the disease. Methods The serum levels of vascular endothelial grow th factor (VEGF), angiopoietin -1 (Ang-1), interleukin-8 (IL-8), granulocyte colony stimulating factor (G -CSF), granulocyte-macrophage colony stimulating factor ( GM-CSF) and monocyte chemotactic protein 1 (MCP -1) in 56 patients w ith moyamoya disease and 26 healthy controls w ere measured by cytometric bead array. Results The serum levels of VEGF (2.81 ± 1.77 pg/ml vs.1.98 ±0.66 pg/ml; t = 3.081, P = 0.003 ) and IL-8 (0.89 ±0.69 pg/ml vs.0.63 ± 0.45 pg/ml; t'=2.0371, P < 0.05) in the moyamoya disease group w ere significantly higher than those in the healthy control group, and the serum level of Ang -1 in the moyamoya disease group w as significantly low er than that in the healthy control group (830.01 ±289.29 pg/ml vs.961.65 ±232.87 pg/ml; t =-2.032, P =0.045). Conclusions There are significant difference in serum levels of VEGF, Ang -1 and IL-8 betw een patients w ith moyamoya disease and healthy controls. The results indicate that angiogenic factors and inflammatory cytokines play some roles in the pathogenesis of moyamoya disease.
