Effects of sarcopenia and exercise training on muscle satellite cells：current status and prospects
10.3969/j.issn.2095-4344.2016.15.017
- VernacularTitle:骨骼肌减少症与运动训练对肌卫星细胞影响的研究现状及展望
- Author:
Qun YU
;
Xiquan WENG
;
Liping WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(15):2248-2254
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The phenomenon of atrophy or reduction of muscle, causing degenerative changes of muscle functions, appears along with age. Sports training, in which muscle satelite cels are of great importance, is beneficial to increase in muscle mass and improvement of muscle function.
OBJECTIVE: To summarize regulatory mechanism of satelite cels in skeletal muscle mass; changes of satelite muscle cels in the degenerative process of muscle mass and strength; declining and reverse effects of sports training intervention; situations and problems of current research and prospective of the future.
METHODS:A computer-based online search was conducted in PubMed database by using the key words of “sarcopenia, skeletal muscle, satelite cels” from 1986 to 2015. The language was limited to English. The eligible papers were further analyzed and reviewed.
RESULTS AND CONCLUSION:A total of 168 papers were screened. Finaly, 39 papers were selected according to the titles and objectives. Skeletal muscle atrophy is shown as II type muscle fiber atrophy, and the II type muscle fiber satelite cel content decreases simultaneously. Exercise is beneficial to increase muscle mass and improve muscle function in older people. Both resistance and endurance trainings can increase the skeletal muscle, especialy the II muscle fiber satelite cel content with a further increase in the satelite cel activation and proliferation. The number and activation degree of satelite cels are related to muscle aging, and satelite cels and proliferation factors regulate muscle cel formation. Therefore, future researches should not only focus on the increase of satelite cel bank, but also explore effective ways to promote the activation of satelite cels, such as exercise training, nutrition and drugs.
