Tendinopathy and the extracellular matrix：to deeply study the key proteins and enzymes in the bone-tendon junction

VernacularTitle:末端病与细胞外基质：骨腱结合部重要蛋白及酶类的关系尚需深入研究
Author: Chunyu LIU ; Xiaoyan HAN ; Lin WANG
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2016;20(15):2265-2272
CountryChina
Language:Chinese
Abstract: BACKGROUND:In recent years, research on tendinopathy is becoming a hot topic in the sports medicine and rehabilitation, and the extracelular matrix plays a considerable role in the occurrence, development and healing of tendinopathy.
OBJECTIVE: To explore the relationship between tendinopathy and the extracelular matrix.
METHODS: CNKI, VIP, CBM, Wanfang, PubMed and Embase were retrieved for articles related to colagen, protein, glycoprotein and matrix remodeling published since 2000.
RESULTS AND CONCLUSION:After tendinopathy, there are obvious changes in colagen, proteoglycans, glycoprotein and related enzymes; and these changes also affect the reconstruction and repair of tendinopathy. Currently, most of researches focus on the tendon rather than the bone-tendon junction. This means that there are no in-depth studies on the correlation between many important proteins and tendinopathy, and the effects of exercise intervention.