Iterative reconstruction improves imaging quality of low er -radiation CT perfusion in patients w ith acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2016.01.007
- VernacularTitle:迭代重建改善缺血性卒中患者低辐射CT 灌注成像的成像质量
- Author:
Fangfang HU
;
Guihua JIANG
;
Junzhang TIAN
;
Jianhao YAN
;
Jin FANG
;
Yaxi ZHANG
;
Xiaofen MA
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Perfusion Imaging;
Multidetector Computed Tomography;
Radiographic Image Interpretation,Computer-Assisted;
Dose-Response Relationship,Radiation
- From:
International Journal of Cerebrovascular Diseases
2016;24(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate w hether the iterative reconstruction (iDose 4 ) technique improves imaging quality of the low-radiation-dose w hole brain CT perfusion (CTP). Methods Thirty-five consecutive patients w ith clinical y suspected ischemic stroke w ere col ected. Bril iance 256 iCT w as used to perform low-radiation-dose w hole brain CTP, and the filtered back projection (FBP) and iDose 4 algorithm w ere used to conduct image reconstruction. The noise and signal to noise ratio of the 2 kinds of reconstruction algorithms, as w el as the imaging quality of each parameter map w ere compared. Results The effective dose of the w hole brain CTP w as 2.2 mSv. Compared w ith FBP, the noise of each region of interest in the iDose4 Tmax map was decreased significantly ( P<0.05) and the signal to noise ratio was increased significantly (P<0.05). The imaging quality scores (median, interquartile range) reconstructed by FPB group w ere significantly low er than by iDose 4 for cerebral blood flow (CBF) map ( 5.00 [3.00-6.00]vs. 6.00 [5.00-6.00]; Z= -2.784, P=0.005), cerebral blood volume (CBV) map ( 6.00 [5.00-6.00] vs. 6.00 [6.00-7.00]; Z= -3.674, P<0.001), and mean transit time (MTT) map (4.00 [3.00-5.00] vs. 5.00 [4.00-6.00]; Z=3.394, P=0.001). The proportions of the poor quality in CBF map ( 34.3%vs. 11.4%;χ2 =7.036, P=0.030), CBV map (11.4%vs.2.9%; χ2 =7.485, P=0.024 ) and MTT map (28.6%vs.11.4%;χ2 =5.318, P=0.070) reconstructed by FBP w ere significantly higher than by iDose 4 . Conclusions The iDose4 technique may improve imaging quality of low er-radiation-dose CTP.
