Clinical observation of low molecular weight heparin combined with astragalus injection in the treatment of diabetic nephropathy
10.3760/cma.j.issn.1008-6706.2016.08.012
- VernacularTitle:低分子肝素钙联合黄芪注射液治疗糖尿病肾病的疗效观察
- Author:
Zheng LI
;
Hua MENG
;
Mei CHEN
;
Qian ZHANG
;
Qin HUANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Low molecular weight heparin calcium;
Astragalus injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1165-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of low molecular weight heparin calcium combined with astraga-lus injection in the treatment of diabetic nephropathy.Methods From January 2013 to December 2014,78 patients with stage III diabetic nephropathy in our hospital were enrolled into the study.They were randomly divided into con-trol group(41 cases) and treatment group(37 cases).The control group received general therapy,such as low protein diets,compound alpha keto acid,insulin,irbesartan,simvastatin.The treatment group was treated with low molecular weight heparin calcium and astragalus injection on the basis of general therapy.The changes of urinary albumin and 24 hours urinary protein after treatment in the two groups were observed.Results After treatment,the negative rate of urinary micro albumin in the treatment group ( 75.68%) was significantly higher than that of the control group (29.27%)(χ2 =16.765,P<0.01).24 hour urinary protein of the treatment group[(176.2 ±82.3)mg/24h]was significantly lower than that of the control group[(223.8 ±87.8)mg/24h](t=2.471,P<0.05).Conclusion Low molecular weight heparin calcium combined with astragalus injection can reduce the proteinuria of diabetic nephropa-thy,it is an effective intervention therapy for early diabetic nephropathy.
