Safety and efficacy of intra-abdominal beacizumab bead sheet resistance combined with hyperthermic intra-peritoneal chemotherapy in treatment of ovarian cancer peritoneal effusion
10.3760/cma.j.issn.1008-6706.2016.08.030
- VernacularTitle:腹腔内贝伐珠单抗联合腹腔热灌注化疗治疗卵巢癌腹腔积液的疗效和安全性
- Author:
Junfang WANG
;
Qin ZHANG
;
Li MAO
;
Lijuan CHENG
;
Huamei ZHANG
- Publication Type:Journal Article
- Keywords:
Ovarian cancer;
Bevacizumab;
Intraperitoneal chemotherapy;
Peritoneal effusion
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1228-1231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical curative effect and safety of intra -abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy in treatment of ovarian cancer perito-neal effusion.Methods 60 patients with ovarian cancer peritoneal effusion in Binzhou Central Hospital from June 2012 to July 2015 were randomly divided into two groups.30 cases in the control group were treated with intraperito-neal hyperthermic perfusion chemotherapy, while 30 patients in the observation group were given intra-abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy.The short-term effica-cy,toxicity and quality of life were compared.Results The effective rate of the observation group was 73.33%, which was significantly higher than 53.33% in the control group,the difference was significant (χ2 =8.55,P<0.05).In the two groups, there were no significant differences on thrombocytopenia, reduced white blood cells and hemoglobin,nausea,vomiting and abdominal pain (χ2 =1.07,1.87,0.90,1.51,2.88 , all P >0 .0 5 ) .The improvement rate of life quality of the observation group was 76.67%,which was significantly higher than 50.00%of the control group,the difference was significant (χ2 =8.06,9.31,all P<0.05).Conclusion Intra-abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy has remarkable curative effect in treatment of ovarian cancer peritoneal effusion,with high safety,and can significantly improve the quality of life of patients,that is suitable for clinical application.
