Relationship between serum 25-hydroxy vitamin D with HCY andβ2-microglobulin in patients with T2DM and its clinical significance
10.3969/j.issn.1673-4130.2016.07.017
- VernacularTitle:T2DM 患者血清25-（OH）D与 HCY 、β2微球蛋白关系及临床意义
- Author:
Xiaojuan FENG
;
Haiying LI
;
Ling JIANG
;
Jibao QIN
;
Zhongwu AN
;
Weibo BO
;
Xia LIU
;
Shumin LIU
- Publication Type:Journal Article
- Keywords:
25-hydroxy vitamin D;
homocysteine;
β2-microglobulin;
type 2 diabetes mellitus
- From:
International Journal of Laboratory Medicine
2016;37(7):912-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum levels of 25‐hydroxy vitamin D[25‐(OH)D] ,homocysteine(HCY) andβ2‐microglob‐ulin(β2‐MG) in the patients with type 2 diabetes mellitus (T2DM ) and to investigate the relationship between serum HCY and β2‐MG with 25‐(OH)D and its clinical significance .Methods A total of 139 cases of T2DM were selected anddivided into 3 groups , the normal albuminuria group for [urinary albumin to creatinine ratio (UACR)< 30 mg/gCr ,45 cases] ,microalbuminuria group (UACR ≥ 30 mg/gCr and < 300 mg/gCr ,48 cases) and massive proteinuria group (UACR ≥ 300 mg/gCr ,46 cases) according to the urinary albumin to creatinine ratio (UACR) .Other 45 individuals undergoing the physical examination were selected as the con‐trol group .The serum 25‐(OH)D level was measured by electrochemiluminescence .Serum HCY level was determined by the enzy‐matic method .Serum β2‐MG level was measured by the latex enhanced immune turbidity method .At the same time ,the biochemical indicators of FBG ,HbA1C ,serum calcium and phosphorus were measured .Results The serum 25‐(OH)D level was decreased with the increase of urinary albumin in the DM patients .And the serum 25‐(OH)D level in the microalbuminuria group and the massive proteinuria group was significantly decreased compared with the normal albuminuria group and the control group ,the difference was statistically significant(P<0 .01) .The serum HCY and β2‐MG levels in the microalbuminuria group and the massive proteinuria group were significantly increased compared with the healthy control group ,the difference was statistically significant (P<0 .05) . Conclusion The serum 25‐(OH)D level is decreased with the increase of urinary albumin in the diabetic patients .The serum HCY andβ2‐MG levels are increased with the increase of urinary albumin and serum 25‐(OH)D level is negatively correlated with the HCY andβ2‐MG levels .
