Pharmacodynamics interaction between propofol and remifentanil under different harmful stimulations analyzed by response surface methodology
- VernacularTitle:丙泊酚和瑞芬太尼在不同伤害性刺激下的响应面分析
- Author:
Zhihui LIAO
;
Nong HE
;
Yonghua YU
;
Ming YI
- Publication Type:Journal Article
- Keywords:
Drug interaction;
Harmful stimulation;
TCI;
Propofol;
Remifentanil;
Response surface analysis
- From:
The Journal of Clinical Anesthesiology
2016;32(4):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the patients hemodynamic reactions to the different stimula-tions under different blood concentrations of propofol with remifentanil.Exerting the response surface methodology,the half of the maximum effective concentration of propofol and the interaction index of propofol with remifentanil were calculated.Methods A total of 120 patients for scheduled abdominal surgery,randomly divided into 12 groups(n = 10).TCI 12 different concentration combinations of propofol with remifentanil,also the the hemodynamic reactions to harmful stimulations of intubation and incising were observed.The data were analyzed by responding surface analysis.Results The in-teraction index of propofol and remifentanil under intubation was 0.523 0±0.223 7,that under inci-sing 0.361 3±0.148 4,half of the maximum effective concentration of propofol for intutation and in-cising was (6.878 7 ± 1.832 1 ) μg/ml and (4.41 1 6 ± 0.902 5 ) μg/ml respectively. Conclusion Propofol and remifentanil have a synergistic inhibitory effect on harmful cardiovascular reaction among Chinese.During the endotracheal intubation,the requirements of half of the maximum effective concentration of propofol and intensity of the synergy with remifentanil are greater than those during the incising.
