New use of old drug:introductiono f the antidepressant effects of ketamine and the underlying mechanisms
10.16571/j.cnki.1008-8199.2016.04.001
- VernacularTitle:老药新用：氯胺酮的快速抗抑郁作用及其机制研究
- Author:
Jianjun YANG
- Publication Type:Journal Article
- Keywords:
Ketamine;
Depression;
Mechanism;
Parvalbumin interneurons
- From:
Journal of Medical Postgraduates
2016;29(4):337-341
- CountryChina
- Language:Chinese
-
Abstract:
Ketamine, a nons-elective N -methyl-D-aspartate (NMDA ) receptor antagonist , is widely used as a general anesthetic in clinical practice. Recent studies have shown that ketamine can produce rapid , effective, and long-lasting antidepressant effects , and the strength of synaptic plasticity induced by inhibitory interneurons , excitatory transmitters , AMPA receptors , and postsynaptic signal pathways may be involved in this procedure .The antidepressant effects of ketamine and the underlying mechanisms are concisely intro -duced in this paper .
