Clinical significance of serum vascular endothelial growth factor on recurrence and/or metastasis following surgery in patients with differentiated thyroid carcinoma
10.3760/cma.j.issn.1008-6706.2016.08.024
- VernacularTitle:分化型甲状腺癌术后复发／转移患者血管内皮生长因子检测的临床意义
- Author:
Hongmin WU
;
Zhenzhu SONG
;
Ruihong YAN
- Publication Type:Journal Article
- Keywords:
Differentiated thyroid cancer;
Vascular endothelial growth factor;
Recurrence and /or me-tastasis;
Serum
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1207-1210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of serum vascular endothelial growth factor ( VEGF ) on recurrence and/or metastasis following surgery in patients with differentiated thyroid carcinoma,and to ana1yze the relationship between serum VEGF and serum thyroglobulin levels.Methods The serum samples were obtained from 25 patients with pulmonary metastasis, 43 cases with locoregional recurrence, 30 cases without recurrence and/or metastasis and 30 normal subjects were selected as control.The levels of serum VEGF were analyzed by enzyme-linked immunosorbent assay( ELISA) ,the levels of serum thyroglobulin were analyzed by chemiluminescence method. Results The level of serum VEGF[(864.3 ±200.3)ng/L] in patients with pulmonary metastasis were significantly higher than that in patients with locoregional recurrence[(393.3 ±96.3)ng/L],without recurrence and /or metasta-sis[(276.6 ±47.7)ng/L] and normal subjects[(268.6 ±36.9)ng/L](t=11.04,14.34,14.66,all P<0.05), while there was no significant difference of serum VEGF level between without recurrence and /or metastasis and normal subjects (t=0.73,P>0.05).It showed linear correlation between serum VEGF and thyroglobulin levels on recurrence and/or metastasis following surgery in patients with differentiated thyroid carcinoma ( r=0.902 2, P<0.001) .Conclusion The serum VEGF level was significantly elevated in patients with locoregional recurrence and pulmonary metastases, the serum VEGF can be used as a auxiliary index to predict recurrence and /or metastasis following surgery in patients with differentiated thyroid carcinoma.
