Effect of bisoprolol combination with perindopril and spironolactone on chronic heart failure caused by rheumatic heart disease
10.3760/cma.j.issn.1008-6706.2016.08.033
- VernacularTitle:比索洛尔联合培哚普利、螺内酯治疗风湿性心脏病慢性心力衰竭的效果观察
- Author:
Leyan CAI
;
Xingfeng XIA
- Publication Type:Journal Article
- Keywords:
Rheumatic heart disease;
Chronic heart failure;
Perindopril;
Bisoprolol;
Spironolactone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1240-1243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the combination treatment effects of bisoprolol,perindopril and spirono-lactone on chronic cardiac failure caused by rheumatic heart disease.Methods 92 patients were randomly divided into the control group (n=45) and observation group (n=47).The observation group received combination usage of bisoprolol,perindopril and spironolactone,while the control group was given regular treatment.Cardiac functions were measured in both two groups.Results The left ventricular end diastolic diameter ( LVEDD) and left ventricular end systolic diameter (LVESD) were significantly decreased in the observation group(t=4.217,5.842,P<0.05),while left ventricular ejection fraction (LVEF) was significantly increased compared with the control group (t=3.164,P<0.05).Conclusion The combination treatment effects of bisoprolol,perindopril and spironolactone has the privilege effects on chronic cardiac failure caused by rheumatic heart disease,which mainly improves cardiac remodeling.