The efficacy of paliperidone in treatment of schizophrenia and its effect on serum prolactin level
10.3760/cma.j.issn.1008-6706.2016.08.035
- VernacularTitle:帕利哌酮治疗精神分裂症的疗效观察及对血清泌乳素水平的影响
- Author:
Zhanhong WEN
- Publication Type:Journal Article
- Keywords:
Paliperidone;
Schizophrenia;
Serum prolactin;
Effect;
Adverse reaction
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1248-1251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of paliperidone in treatment of schizophrenia and its influence on serum prolactin levels.Methods 52 cases of schizophrenia were diagnosed,and they were divid-ed into two groups according to randomized single-blind method.26 patients in the control group were given oral risperidone treatment, while 26 cases in the observation group were given oral paliperidone.The clinical treatment effect,incidence of adverse reactions and serum prolactin levels were compared.Results The total effective rate of the two groups showed no significant difference (χ2 =1.44,P>0.05).After 4 weeks,8 weeks,12 weeks treatment, the serum prolactin levels of the observation group were (42.86 ±17.54)μg/L,(35.47 ±18.29)μg/L,(26.14 ± 17.38)μg/L,which were significantly increased than before treatment[(10.21 ±4.09)μg/L](t =8.44,6.89, 6.03,all P<0.05),and compared with the control group at the respective time points,the differences were significant (t=8.23,8.01,7.67,all P<0.05).After 4 weeks,8 weeks,12 weeks treatment,the serum prolactin levels of the control group were (56.72 ±11.38)μg/L,(51.26 ±21.48)μg/L,(48.31 ±22.76)μg/L,which were significantly increased than before treatment (t=10.43,9.30,7.83,all P<0.05).The incidence rate of adverse reactions in the observation group was 23.08%,which was significantly lower than 53.85% of the control group,the difference was significant between the two groups (χ2 =10.34,P<0.05).Conclusion Paliperidone in the treatment of schizophre-nia had good curative effect, and it can effectively improve the serum prolactin levels in patients, and it had less adverse reactions,it was safe,which should be applied and promotion of great value.
