Efficacy observation of pegaspargase combined with intensity modulated conformal radiotherapy in the treatment of 20 patients with early-stage nasal NK/T cell lymphoma

VernacularTitle:培门冬酶联合调强适形放疗治疗早期鼻腔NK／T细胞淋巴瘤20例效果观察
Author: Xiaomei LIU ; Yunhong HUANG ; Yunfei HU ; Yang SONG ; Jiaying GAN
Publication Type:Journal Article
Keywords: Lung neoplasms; Lymphoma,T-cell,peripheral; Prognosis
From: Journal of Leukemia & Lymphoma 2016;25(3):186-188
CountryChina
Language:Chinese
Abstract: Objective To study the clinical characteristics, diagnosis, treatment and prognosis of primary pulmonary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Methods Two cases of primary pulmonary PTCL-NOS were studied and relevant literature were reviewed. Results Case 1 diagnosed as primary pulmonary PTCL-NOS was a 44 years old woman and disease progressed after GLD (Gem+L-OHP+ DXM) chemotherapy regimen. At last, the patient died of respiratory failure after one month. Case 2 diagnosed as primary pulmonary PTCL-NOS was a 46 years old man and reach partial response after CHOP regimen, and still alive now.Conclusion Primary pulmonary PTCL-NOS is very rare. It is easy to be misdiagnosed due to non-specific clinical and imaging manifestations. Acquiring enough tissue specimens for pathologic examination is the key to a definitive diagnosis. At present, there is no standard chemotherapy regimen for these patients, the prognosis is relatively poor.