Effect of ulinastatin on serum concentration of S100βprotein and NSE in patients undergoing supratento-rial tumor resection
- VernacularTitle:乌司他丁对幕上肿瘤切除术患者血清 S100β蛋白和神经原特异性烯醇化酶的影响
- Author:
Shile LIU
;
Zumin XING
;
Fengxian LI
;
Liuqing YUAN
;
Ping XU
;
Shiyuan XU
- Publication Type:Journal Article
- Keywords:
Supratentorial tumor resection;
Ulinastatin;
S100βprotein;
Neuronsp ecific eno-lase
- From:
The Journal of Clinical Anesthesiology
2016;32(4):325-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the serum concentration of S100βprotein (S100β)and neuron specific enolase (NSE)in patients undergoing supratentorial tumor resection with ulinastatin treat-ment.Methods Twenty-four patients with supratentorial tumor resection,aged 18-65 years,ASA Ⅰor Ⅱ,were randomly divided into the control group (group A,n =12)and ulinastatin group (group U,n =12).Patients in group U received ulinastatin (2 kU/kg)at the beginning of the surgery,with the continuous dose of 1 kU·kg-1 ·h-1 till the end of the operation.Group A received equivalent volume of saline solution as the vehicle control.Blood samples were taken from the artery and jugular venous bulb before induction of anesthesia (T1 ),skin incision (T2 ),1 h after dura openning (T3 ),at the closure of dura (T4 ),at the end of operation (T5 )and 24 h after operation (T6 )to analyze the concentration of S100β and NSE.The concentration of S100β and NSE were determined by ELISA. Results The concentration of serum S100β and NSE increased more significantly higher at T3-T6 in group A than group U (P <0.01).The concentration of serum S100βand NSE in group U were lower than those in group A at T3-T5 (P < 0.01 ).Conclusion Ulinastatin reduces the concentration of serum S100βand NSE during surgery,indicating it alleviates brain injury during supratentorial tumor resection.
