Cancer genomics-related data management and its application
10.3969/j.issn.1671-3982.2016.04.014
- VernacularTitle:癌症基因组学相关数据管理与应用探析
- Author:
Liu SHEN
;
Haihong GUO
;
Si ZHENG
;
Jiao LI
- Publication Type:Journal Article
- Keywords:
Scientific data sharing;
Open data;
TCGA;
Data management
- From:Chinese Journal of Medical Library and Information Science
2016;25(4):62-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide reference for developing and perfecting the open resources of national-wide cancer genomics-related data by collecting, systematizing, organizing, sharing and applying the related data of the National Genome Atlas ( TCGA) Program. Methods The technical process, sharing and use of TCGA Program data were in-vestigated. Results TCGA established the whole linkage data management process by cooperating with multiple cen-ters, including tissue sample collection, processing, quality control, sequencing, characteristics analysis, data sharing and application of research achievements. The data were classified according to the related cancer, data types and their processing. The mutation, amplification and deficit of related cancer characteristic genes and the af-fected signaling pathways were studied according to the two sharing mechanisms underlying open access and con-trolled access to the collected data and individual data. Conclusion Studies on TCGA Program can provide experi-ences and reference in data management for the implementation of large scale TCGA Program.
