Relationship of arginase Ⅰprotein genetic polymorphisms with chronic periodontitis and coronary heart disease
10.3969/j.issn.1001-3733.2016.01.026
- VernacularTitle:精氨酸酶Ⅰ基因型与慢性牙周炎、冠心病的相关性研究
- Author:
Jijun SUN
;
Jing WANG
;
Yan ZHANG
;
Qingshan WANH
;
Aiqin WANG
- Publication Type:Journal Article
- Keywords:
Chronic periodontitis;
Coronary heart disease;
ArginaseⅠ(Arg Ⅰ);
Gene polymorphism
- From:
Journal of Practical Stomatology
2016;32(1):120-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of arginase Ⅰ(ArgⅠ)rs2781 666 G/T genotype with the susceptibility of mod-erate and severe chronic periodontitis(MSP)and coronary heart disease(CHD).Methods:DNA was obtained from buccal swabs of 50 patients with MSP,46 with CHD,42 with MSP and CHD,and 50 matched healthy controls.Genotypes of rs2781 666 G/T was analyzed by PCR-PFLP method.The genotype distribution in the 4 groups was compared.Results:Higher representation of ArgⅠrs2781 666 al-lele T was found in CHD group than that in the healthy control individuals(P <0.01 ),and there was no statistical differences among the other 3 groups.Conclusion:Allele T of ArgⅠrs2781 666 may be associated with CHD susceptibility.
