Advance in memory NK cells study
10.3969/j.issn.1000-484X.2016.04.001
- VernacularTitle:记忆性NK细胞的最新研究进展
- Author:
Tingting LI
;
Hui PENG
;
Rui SUN
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
NK cells;
Memory;
Function;
Model
- From:
Chinese Journal of Immunology
2016;32(4):449-459
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer ( NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against microbial pathogens and tumors in an antigen-independent manner.Recently,NK cells have been shown to possess features of a-daptive immunity with immunological memory in a manner similar to that of T and B cells.Three major viewpoints of NK cell memory initially arose from the studies of NK cell memory to recall to mouse cytomegalovirus ( MCMV ) , cytokine and skin-contact hypersensitive chemical antigens.Currently,NK cell memory has been reported in acute infection of mouse HSV ,influenza virus,HCMV and simian immunodeficiency virus ( SIV).Here,we review the latest discoveries and unsolved questions regarding NK cell memory in these models.Studies to reveal the mechanisms for NK cell memory may provide opportunities for the therapeutic use of NK cells in in -fectious diseases and cancer.
