Preparation and Quality Control of Thermosensitive Nasal Gel of Ephedrine Hydrochloride and Diphen-hydramine Hydrochloride
- VernacularTitle:苯麻鼻用温敏凝胶的制备及质量控制
- Author:
Jun ZHOU
;
Lei TANG
;
Ruifeng LIU
;
Zhuoya LI
- Publication Type:Journal Article
- Keywords:
Ephedrine hydrochloride;
Diphenhydramine hydrochloride;
Thermosensitive nasal gel;
HPLC
- From:
China Pharmacist
2016;19(3):596-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare the thermosensitive nasal gel of ephedrine hydrochloride and diphenhydramine hydrochloride and establish its quality control method. Methods:The amounts of P407, P188 and PEG 6000 were optimized by an orthogonal test with the gelling temperature as the index. An HPLC method was established to determine the contents of ephedrine hydrochloride and di-phenhydramine hydrochloride. Results:The optimum amount of P407, P188 and PEG 6 000 was 19%, 2% and 1%, respectively. The linear range of ephedrine hydrochloride was 1.600 0-2.400 0 mg·ml-1(r=0.999 6), and the average recovery was 99.76%with RSD of 1. 02%(n=9). The linear range of diphenhydramine hydrochloride was 0. 160 0-0. 240 0 mg·ml-1(r=0. 999 7), and the average recovery was 101. 27% with RSD of 1. 10%(n=9). Conclusion:The formula design and preparation technology of the gel are feasible. The HPLC method is suitable for the quality control of the preparation.
