Expression of survivin and programmed cell death 5 in mucoepidermoid carcinoma and their clinical sig-nificance

VernacularTitle:Survivin 和 PDCD5在黏液表皮样癌组织中的表达及临床意义
Author: Beibei QU ; Jinhua ZUO ; Yuhong ZHU ; Lifang WANG
Publication Type:Journal Article
Keywords: Mucoepidermoid carcinoma(MEC); Survivin; Programmed cell death 5(PDCD5); Immunohisto-chemistry
From: Journal of Practical Stomatology 2016;32(2):225-229
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of Survivin and programmed cell death 5(PDCD5)protein in mucoepidermoid carcinoma(MEC).Methods:Survivin and PDCD5 were detected by immunohistochemical staining in 20 cases of normal parotid tis-sue(group A),40 cases of pleomorphic adenoma(group B)and 45 cases of MEC tissues(group C).Results:The positive expres-sion ratio of Survivin in group A,B and C was 10.0%,27.5% and 55.6% respectively(χ2 =14.556,P <0.01),while that of PD-CD5 was 85%,65% and 33.3% respectively (χ2 =17.439,P <0.01).The expression of survivin or PDCD5 was related with dif-ferentiation,lymph node metastasis and TNM staging of MEC.Survivin and PDCD5 showed a negative correlation in MEC(χ2 =4.500,P =0.034,γs =-0.316).Conclusion:Survivin over-expression and PDCD5 down-expression may play a role in the de-velopment and progress of mucoepidermoid carcinoma.