A comparative study of dexmedetomidine and nicardipine in the induction of controlled hypotension in the patients during orthognathic surgery
10.3969/j.issn.1001-3733.2016.02.022
- VernacularTitle:右美托咪定与尼卡地平用于正颌手术患者控制性降压的对比研究
- Author:
Dan ZHOU
;
Ruichang LIU
;
Xudong YANG
;
Fang HAN
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Nicardipine;
Orthognathic surgery;
Controlled hypotension
- From:
Journal of Practical Stomatology
2016;32(2):256-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of dexmedetomidine and nicardipine in the induction of controlled hypotension in the pa-tients during orthognathic surgery.Methods:60 patients were randomly divided into 2 groups(n =30).The patients in group D were intravenously pumped with 1 μg/kg dexmedetomidine for 10 min followed by 0.2 ~0.7 μg/(kg·h).Those in group N were pumped with nicardipine for an initial dose of 0.75 μg/(kg·min)followed by 0.2 ~0.5 μg/(kg·min).HR,MAP were recorded before in-duction (T0 ),start of hypotension(T1 ),10 min(T2 ),20 min (T3 ),30 min(T4 )and 60 min(T5 )after hypotension,10 min(T6 ), 30 min(T7 )after stop of hypotension,and at the end of surgery(T8 ).The remifentanil dosage was recorded.Riker sedation-agitation score (RSAS)before extubation and Ramsay score 5 min after extubation were observed.Results:Comparing with T0 ,MAP at T2 -T7 in the 2 groups were significantly decreased(P <0.05).The intraoperative remifentanil consumption in group D was significantly lower than that in group N (P <0.05).The Ramsay score in group D was significantly higher than that in group N(P <0.05).The RSAS in group D was significantly lower than that in group N(P <0.05).Conclusion:Both dexmedetomidine and nicardipine are safe for con-trolled hypotension in providing ideal surgical field during orthognathic surgery.Dexmedetomidine can produce more stable hemdynamic indexes and offer more advantage in postoperative sedation.
