Effects of metronidazole and amoxicillin combination on MMP-1,MMP-8 and TIMP-1 level in gingival crevic-ular fluid of patients with aggressive periodontitis
- VernacularTitle:甲硝唑联合羟氨苄青霉素对侵袭性牙周炎患者龈沟液中 MMP-1、MMP-8和 TIMP-1水平的影响
- Author:
Hailiang ZHANG
;
Zhiyong SU
;
Yuyan PEI
;
Fang LI
- Publication Type:Journal Article
- Keywords:
Metronidazole;
Amoxicilline;
Matrix metalloproteinases-1(MMP-1);
Matrix metalloproteinases-8(MMP-8);
Tissue inhibitors ofmatrix metalloproteinases(TIMP-1);
Aggressive periodontitis(AgP)
- From:
Journal of Practical Stomatology
2016;32(2):285-288
- CountryChina
- Language:Chinese
-
Abstract:
40 cases(control group)with aggressive periodontitis (AgP)received scaling and root planning (SRP)and 38 cases(test group)received SRP followed by oral administration of amoxicillin plus metronidazole for 7 d.Gingival crevicular fluid samples were exam-ined for the levels of MMP-1,MMP-8 and tissue TIMP-1 by ELISA before therapy,3 and 6 months after therapy,TIMP-1 /MMP-1 and TIMP-1 /MMP-8 ratios were calculated.The levels of MMP-1 and MMP-8 were decreased in both groups (P <0.05)at 3 and 6 months after therapy.TIMP-1 /MMP-1 and TIMP-1 /MMP-8 ratios were increased in the 2 groups(P <0.05)after treatment,3 months after therapy the ratio in test group was higher than that in control group(P <0.05).
