Relationship between bone relapse in pediatric acute lymphoblastic leukemia and gene mutation
10.3760/cma.j.issn.1673-4408.2016.05.007
- VernacularTitle:儿童急性淋巴细胞白血病复发与基因突变相关性
- Author:
Jinglin WANG
- Publication Type:Journal Article
- Keywords:
Pediatric acute lymphoblastic leukemia;
leukemia relapse;
Gene mutation;
Child
- From:
International Journal of Pediatrics
2016;43(5):373-376
- CountryChina
- Language:Chinese
-
Abstract:
Acute lymphoblastic leukemia is a major type of childhood cancer.It is an obstacle to cure for young patients with relapsed acute lymphoblastic leukemia.Recent investigations into the mechanism of relapse in pediatric acute lymphoblastic leukemia indicate the relationship between gene abnormalities and the relapse of pediatric acute lymphoblastic leukemia.An increasing number of gene abnormalities have been confirmed to be related with relapse of this disease, including deletion of IKZF1 and mutations of JAK, CREBBP,CEBPE and ARID5B.This paper reviews the details about the influence of the various gene mutations on the relapse of the pediatric acute lymphoblastic leukemia.
