Analysis of One Case of Irinotecan-induced Delayed Diarrhea
- VernacularTitle:1例伊立替康致迟发性腹泻的病例分析
- Author:
Hui XIA
;
Xuan WANG
;
Zhiyi WANG
;
Hong ZHU
;
Mingxue CAO
;
Lili WANG
;
Fengqun LIU
- Publication Type:Journal Article
- Keywords:
Irinotecan;
Delayed diarrhea;
Loperamide;
Pharmaceutical care;
Clinical pharmacist
- From:
China Pharmacist
2016;19(3):543-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze one case of delayed diarrhea caused by irinotecan. Methods:The pathogeny, mechanism, ge-netics and treatment of the case were analyzed. Results:Delayed diarrhea was the dose-limited toxicity of irinotecan, which was related with the cytotoxicity of the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Genetic polymorphism was one of important risk factors, especially UGT1A1 polymorphisms could be used as a predictor for the diarrhea. The pharmacotherapy of the diarrhea was ef-fective and rational, and the clinical pharmacist provided rational pharmaceutical care for the patient. Conclusion:It is very important to enhance pharmaceutical care for the patients treated with irinotecan.
