Effects of Galanin Receptor 2 Agonist on Depression-like Behavior in Chronic Mild Stress Model Rats
10.3969/j.issn.1006-9771.2016.03.008
- VernacularTitle:甘丙肽2型受体激动剂对慢性温和应激模型大鼠抑郁样行为的影响
- Author:
Pan ZHANG
;
Bo LIU
;
Tong WANG
;
Hui LI
;
Yutao YANG
;
Zhiqing XU
- Publication Type:Journal Article
- Keywords:
chronic mild stress;
depression;
galanin receptor 2 agonist;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(3):278-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of intracerebroventricular injection of AR-M1896, a galanin receptor 2 agonist, on depres-sion-like behavior in rat chronic mild stress (CMS) model. Methods 48 Sprague-Dawley rats were randomly assigned into control group, CMS group, CMS artificial cerebrospinal fluid (aCSF) group and CMS AR-M1896 group equally. The control group received no interven-tion, and the other groups were established chronic mild stress model. After six-week of stress, forced swim test and sucrose preference test were conducted to identify the CMS rats. AR-M1896 or aCSF was injected into the lateral ventricle of CMS AR-M1896 group and CMS aC-SF group, respectively. The immobility time and climbing time in the forced swim test were analysed, and the sucrose consumption percent-age in the sucrose preference test was measured. Results The immobility time decreased (F=11.998, P<0.01), climbing time increased (F=8.268, P<0.05), and the sucrose consumption percentage increased (F=10.352, P<0.01) in CMS AR-M1896 group, compared with CMS aC-SF group. Conclusion Intracerebroventricular administration of galanin receptor 2 agonist AR-M1896 is effective on depression in CMS model rats.
