HNA frequencies in the Kinh ethnic of Vietnam population, determined by polymerase chain reaction with sequence-specific primers
- Author:
Bach Khanh Hoa
- Publication Type:Journal Article
- Keywords:
Human neutrophil
- MeSH:
Polymerase Chain Reaction;
Antigens;
Neutropenia;
Antibodies
- From:Journal of Vietnamese Medicine
2004;294(1):29-33
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The human neutrophil antigens (HNA) are often targets of granulocyte antibodies causing immune neutropenia. Typing for HNA is useful in a veriety of clinical situations. The author developed a method for genotyping for HNA-1 by means of the PCR ampification with sequence specific primer (PCR-SSP) technique. The typing results were available within 5 hours each time for one blood sample tested. In 61 granulocytes samples, the gen frequencies were 64.7% for HNA-1a and 35.2% for HNA-1b. The HNA-1a gene is more frequent in the Kinh population than the HNA-1b
