Affects of the amount of grafted cells on acute graft versus host disease after haploid hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2016.01.015
- VernacularTitle:供者细胞回输数量对单倍型造血干细胞移植后急性移植物抗宿主病的影响
- Author:
Peng CHEN
;
Huiren CHEN
;
Xuepeng HE
;
Zhi GUO
;
Kai YANG
;
Yuan ZHANG
;
Xiaodong LIU
;
Bing LIU
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Monocytes;
Antigens;
CD34;
Graft vs host disease
- From:
Journal of Leukemia & Lymphoma
2016;25(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the amount of grafted cells and the incidence of acute graft versus host disease (aGVHD) after haploid hematopoietic stem cell transplantation (haplo-HSCT). Methods Data of 68 patients who underwent haplo-HSCT from Jan 2009 to Dec 2013 were analyzed retrospectively. Influences of different factors on the incidence of Ⅲ-Ⅳ degree of aGVHD after HSCT were evaluated. Results 68 patients including 42 males and 26 females were 5/10-9/10 HLA match with 19 father donors, 24 mother donors, 16 sibling donors and 9 children donors. 51 patients not suffered Ⅲ-Ⅳdegree of aGVHD included 32 males and 19 females with the mean age of 20 years old (5-55 years old). 17 patients sufferedⅢ-Ⅳdegree of aGVHD including 10 males and 7 females with the mean age of 23 years old (5-54 years old). There were no significant differences in the amount of the grafted mononuclear cells (MNC) and CD34+cells, and the white blood cell counts (WBC) and platelet count (Plt) recovered time between two groups (P>0.05). However, MNC number was related to CD34+cell number (P<0.05) and WBC recover time (P<0.05), and the CD34+cells number was related to WBC and Plt recover time (P< 0.05). Conclusion The incidence of Ⅲ-Ⅳ degree of aGVHD is unrelated to the amount of grafted MNC, and CD34+cells.
